 หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Study on Sulfadimethylpyrimidine in Pangasius pangasius Following the Intravenous, Intramuscular and Oral Drug Administration ) ผู้เขียน: S. Sirivejapandu, P. Chai-anan, M. Limpoka, W. Chuapoehuk, U. Na-Nakorn, O. Lauhawinit สื่อสิ่งพิมพ์:pdf AbstractThe disposition of sulfadimethylpyrimidine was studied in Pangasius pangasius following the intravenous, intramuscular and oral drug dosing. The drug was administered as 25% solution at the dosage of 107.25 mglkg. Blood samples were collected via the caudal blood vessels at specific times and determined by the Direct and Total method of Bratton and Marshall. The drug was incompletely absorbed following intramuscular and oral administration. The bioavailability were 69.02% and 12.36% following the intramuscular and oral dosing, respectively. The Three Compartment Model would be used to describe the disposition of the drug in Pangasius pangasius. Estimation of all the rate constant was also obtained. |
หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Study of Sulfamonomethoxine in Catfish (Pangasius pangasius) Following the Intravenous, Intramuscular and Oral Drug Administration) ผู้เขียน:M. Limpoka, P. Chai-anan, S. Sirivejapandu, R. Kanchanomai, O. Lawhavinit, W. Chuapoehuk, U. Na Nakorn สื่อสิ่งพิมพ์:pdf Abstract The disposition of sulfamonomethoxine was studied in Pangasius pangasius following the intravenous, intramuscular and oral drug administration. The drug was administered as 20% solution at the dosage of 200 mg/kg. body weight. Blood samples were collected at specific times via the caudal blood vessels and determined by the Direct and Total method of Bratton and Marshall. Following intravenous administration, the drug was excreted within 108 hours. The maximum plasma concentration reached 32.72 mg % and 28.4 mg % following the intravenous and intramuscular dosing and maintained above 5 mg % for 24 hours. The drug was incompletely absorbed after oral administration. Approximately 70.57% and 16.63% of the given dose were absorbed following intramuscular and oral administration, respectively. The biphasic shape of the plasma disappearance curve suggested that a two compartment model would be used to describe the behavior of the drug in catfish. |